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Minimal residual disease-directed immunotherapy for high-risk myelodysplastic syndrome after allogeneic hematopoietic stem cell transplantation

Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang

Frontiers of Medicine 2019, Volume 13, Issue 3,   Pages 354-364 doi: 10.1007/s11684-018-0665-5

Abstract: The efficacy of minimal residual disease (MRD)-directed immunotherapy, including interferon- (IFN- )

Keywords： donor leukocyte infusion     hematopoietic stem cell transplantation     interferon-<font style=    

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High-expression of recombinant human concensus interferon-α by Pichia pastoris

HAO Yuyou, SHI Qiqi, HE Yun, ZHUANG Yingping, WANG Yonghong, ZHANG Siliang, CHU Ju, LIU Zhimin

Frontiers of Chemical Science and Engineering 2007, Volume 1, Issue 4,   Pages 399-403 doi: 10.1007/s11705-007-0073-x

Abstract: The present work focused on the high expression of recombinant human consensus interferon- (cIFN) by

Keywords： bioactivity     pastoris     maximum     induction     optimized    

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Novel hierarchical yolk-shell

Xiqing Luo, Miaomiao Jiang, Kun Shi, Zhangxian Chen, Zeheng Yang, Weixin Zhang

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 5,   Pages 1322-1331 doi: 10.1007/s11705-021-2036-z

Abstract: For high performance supercapacitors, novel hierarchical yolk-shell -Ni(OH) /Mn O microspheres were controllably synthesized using a facile two-step method based on the solvothermal treatment. The unique -Ni(OH) based yolk-shell microstructures decorated with numerous interconnected nanosheets and the hetero-composition features can synergistically enhance reactive site exposure and electron conduction within the microspheres, facilitate charge transfer between electrolyte and electrode materials, and release structural stress during OH chemisorption/desorption. Moreover, the Mn O sediments distributed over the -Ni(OH) microspheres can serve as an effective protective layer for electrochemical reactions. Consequently, when tested in 1 mol·L KOH aqueous electrolyte for supercapacitors, the yolk-shell -Ni(OH) /Mn O microspheres exhibited a considerably high specific capacitance of 2228.6 F·g at 1 A·g and an impressive capacitance retention of 77.7% after 3000 cycles at 10 A·g . The proposed -Ni(OH) /Mn O microspheres with hetero-composition and unique hierarchical yolk-shell microstructures are highly promising to be used as electrode materials in supercapacitors and other energy storage devices.

Keywords： <font style=    

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Joint slip investigation based on finite element modelling verified by experimental results on wind turbine lattice towers

Saleh YAGHOOBI, Ahmad SHOOSHTARI

Frontiers of Structural and Civil Engineering 2018, Volume 12, Issue 3,   Pages 341-351 doi: 10.1007/s11709-017-0393-y

Abstract: Thereupon, damping ratios (<font style="font-family:Symbol">zfont>) for different types of connections

Keywords： Joint slip     cyclic loading     Finite element modelling     Experimental joint behavior     damping ratios (<fontstyle=    

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Interferon-α salvage treatment is effective for patients with acute leukemia/myelodysplastic syndrome

Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang

Frontiers of Medicine 2019, Volume 13, Issue 2,   Pages 238-249 doi: 10.1007/s11684-017-0599-3

Abstract: The efficacy of salvage interferon-α (IFN-α) treatment was investigated in patients with unsatisfactory

Keywords： interferon-α     hematopoietic stem cell transplantation     minimal residual disease     donor lymphocyte infusion    

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Testing of tuberculosis infection among Chinese adolescents born after terminating the Bacillus Calmette--Guérin booster vaccination: subgroup analysis of a population-based cross-sectional study

Hengjing Li, Henan Xin, Shukun Qian, Xiangwei Li, Haoran Zhang, Mufei Li, Boxuan Feng, Qi Jin, Lei Gao

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 528-535 doi: 10.1007/s11684-017-0573-0

Abstract:

The prevalence of tuberculosis infection among adolescents born after terminating the Bacillus Calmette–Guérin (BCG) booster vaccination in China was estimated using tuberculin skin testing (TST) and QuantiFERON-TB Gold assay (QFT) to investigate the influence of neonatal BCG vaccination on the performance of TST. Data analysis was conducted for 2831 eligible participants aged 5–15 years from the baseline survey of a population-based multi-center prospective study. The prevalence rates of TST (induration≥10 mm) and QFT positivity were 9.3% (264/2827) and 2.5% (71/2831), respectively. The rate of QFT indeterminate result was 2.2% (62/2831). The overall agreement between TST and QFT was low (concordance= 88.0%; κ coefficient= 0.125). Only TST was positively associated with BCG vaccination with an adjusted odds ratio of 1.71 [95% confidence interval, 1.26–2.31]. A history of close contact with patients of active TB was significantly associated with positivity for TST and QFT. Our results suggested that BCG neonatal vaccination still affects TST performance, and a two-step approach might be considered for TB infection testing among adolescents in China.

Keywords： tuberculin skin test     interferon-γ release assays     adolescent     agreement    

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Anti-β2GPI/β2GPI complexes induce platelet activation and promote thrombosis via p38MAPK: a pathway to targeted therapies

Wenjing Zhang, Caijun Zha, Xiumin Lu, Ruichun Jia, Fei Gao, Qi Sun, Meili Jin, Yanhong Liu

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 680-689 doi: 10.1007/s11684-018-0673-5

Abstract: Anti- glycoprotein I (anti- GPI) antibodies are important contributors to the development of thrombosis. Anti- GPI antibody complexes with GPI are well known to activate monocytes and endothelial cells via the intracellular NF- B pathway with prothrombotic implications. By contrast, the interaction of anti- GPI/ GPI complexes with platelets has not been extensively studied. The p38 mitogen-activated protein kinase (MAPK) pathway has been recognized to be an important intracellular signaling pathway in the coagulation cascade and an integral component of arterial and venous thrombosis. The present study reveals that levels of anti- GPI/ GPI complexes in sera are positively associated with p38MAPK phosphorylation of platelets in thrombotic patients. Furthermore, SB203580 inhibits anti- GPI/ GPI complex-induced platelet activation. Thrombus formation decreased in mice after treatment with anti- GPI/ GPI complexes. In conclusion, p38MAPK may be a treatment target for anti- GPI antibody-associated thrombotic events.

Keywords： anti-<font style=    

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Phase separation in cGAS-STING signaling

Frontiers of Medicine   Pages 855-866 doi: 10.1007/s11684-023-1026-6

Abstract: Biomolecular condensates formed by phase separation are widespread and play critical roles in many physiological and pathological processes. cGAS-STING signaling functions to detect aberrant DNA signals to initiate anti-infection defense and antitumor immunity. At the same time, cGAS-STING signaling must be carefully regulated to maintain immune homeostasis. Interestingly, exciting recent studies have reported that biomolecular phase separation exists and plays important roles in different steps of cGAS-STING signaling, including cGAS condensates, STING condensates, and IRF3 condensates. In addition, several intracellular and extracellular factors have been proposed to modulate the condensates in cGAS-STING signaling. These studies reveal novel activation and regulation mechanisms of cGAS-STING signaling and provide new opportunities for drug discovery. Here, we summarize recent advances in the phase separation of cGAS-STING signaling and the development of potential drugs targeting these innate immune condensates.

Keywords： biomolecular condensates     phase separation     cGAS-STING pathway     cGAS     STING     cGAMP     interferon    

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Inverse kinematics analysis and numerical control experiment for PRS-XY style hybrid machining tool

JIA Dongyong, ZHANG Jianmin, SUN Hongchang, NIU Zhigang

Frontiers of Mechanical Engineering 2007, Volume 2, Issue 2,   Pages 235-238 doi: 10.1007/s11465-007-0041-7

Abstract: This paper analyzed the inverse kinematics for the new Parallel rotate slider- axes (PRS-) style hybridThe program for the PRS-XY style hybrid machining tool in accordance with the program manner for the

Keywords： numerical     accordance     transform formula     virtual     slider-    

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Integrated fuzzy lectotype optimization for pile－style foundations of offshore wind turbines

Zhai Gangjun,Li Yugang,Kang Haigui

Strategic Study of CAE 2010, Volume 12, Issue 11,   Pages 40-46

Abstract:

style="text-align: justify;">Offshore wind energy is one of the most attractive sources of renewableConsidering various 13 factors of optimization objects and 4 design types of pile-style foundation, themethod has been successfully used to an offshore wind farm for the lectotype optimization of pile-style

Keywords： offshore wind turbines     pile-style foundation     lectotype optimization     fuzzy decision    

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Control of lupus activity during pregnancy via the engagement of IgG sialylation: novel crosstalk between IgG sialylation and pDC functions

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 549-561 doi: 10.1007/s11684-022-0965-7

Abstract: The type I interferon signature of pregnant patients with SLE was negatively correlated with the level

Keywords： pregnancy     IgG glycome     type I interferon     systemic lupus erythematosus    

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Dynamic performance of submerged floating tunnel with different mooring styles subjected to anchor cable failure

Frontiers of Structural and Civil Engineering doi: 10.1007/s11709-023-0932-7

Abstract: The present study can serve as a reference for the safer designs of the SFT mooring style.

Keywords： dynamic behaviors     submerged floating tunnel     cable failure     mooring style     progressive failure    

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Structure style selection and key structural design of herringbone steel middle pylon of three-pylon

Hua Xin,Han Dazhang,Zhou Yanfeng,Xu Ruifeng

Strategic Study of CAE 2010, Volume 12, Issue 4,   Pages 37-42

Abstract:

style="text-align: justify;">The total stiffness of a three-pylon suspension bridge is relatively

Keywords： three-pylon suspension bridge     steel middle pylon     structure style selection     key structural     design中国工程科学    

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Deep-seated Rupture Zone—a New Seismotectonic Style

Li Yuanjun

Strategic Study of CAE 2006, Volume 8, Issue 4,   Pages 12-18

Abstract:

In hydraulic engineering, deep-seated rupture zones have been discovered in some dam areas, such as Heishanxia of Huanghe River, Jinpingshan of Yalongjiang River and others. It is a new geological structure phenomenon. deep-seated rupture zones are usually situated in the pleistoseismic generating faults. Historic earthguakes frequently occur along the active structure zone. Deep seated rupture zones are 300 m or more beneath the surface, far exceeding the depth of surface unloading range. They are bound up with the dynamics effect of rock mass during earthquake happening. This paper discussed the seismologic reasons for the occurrence of deep seated rupture zones according to elastic wave kinetics.

Keywords： deep-seated rupture zone     pleistoseismic generating fault     unloading     rock dynamics    

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Qian Xuesen—An Example for Scientific and Technological Circles to Learn From

Tu Yuanji

Strategic Study of CAE 2002, Volume 4, Issue 2,   Pages 1-7

Abstract:

Qian Xuesen´s life-time is reviewed in this article and his excellent character and behaviour that are benefited from good family breeding and school education are highly praised. His brilliant talent and plentiful attainments after receiving his training under Theodore von Kármán in the United States are introduced. The article describes, with host of facts that are rarely known, Qian´s unrelenting struggle for returning homeland and the contributions he made with all his heart to China´s space undertaking after he returned to China. Finally, the article reveals Qian´s lofty ideological level and virtuous character towards money, honour and position.

Keywords： life-time     seek knowledge     tackle key problems in science and technology     work style     thinking and moral    

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Title Author Date Type Operation

Minimal residual disease-directed immunotherapy for high-risk myelodysplastic syndrome after allogeneic hematopoietic stem cell transplantation

Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang

Journal Article

High-expression of recombinant human concensus interferon-α by Pichia pastoris

HAO Yuyou, SHI Qiqi, HE Yun, ZHUANG Yingping, WANG Yonghong, ZHANG Siliang, CHU Ju, LIU Zhimin

Journal Article

Novel hierarchical yolk-shell

Xiqing Luo, Miaomiao Jiang, Kun Shi, Zhangxian Chen, Zeheng Yang, Weixin Zhang

Journal Article

Joint slip investigation based on finite element modelling verified by experimental results on wind turbine lattice towers

Saleh YAGHOOBI, Ahmad SHOOSHTARI

Journal Article

Interferon-α salvage treatment is effective for patients with acute leukemia/myelodysplastic syndrome

Xiaodong Mo, Xiaohui Zhang, Lanping Xu, Yu Wang, Chenhua Yan, Huan Chen, Yuhong Chen, Wei Han, Fengrong Wang, Jingzhi Wang, Kaiyan Liu, Xiaojun Huang

Journal Article

Testing of tuberculosis infection among Chinese adolescents born after terminating the Bacillus Calmette--Guérin booster vaccination: subgroup analysis of a population-based cross-sectional study

Hengjing Li, Henan Xin, Shukun Qian, Xiangwei Li, Haoran Zhang, Mufei Li, Boxuan Feng, Qi Jin, Lei Gao

Journal Article

Anti-β2GPI/β2GPI complexes induce platelet activation and promote thrombosis via p38MAPK: a pathway to targeted therapies

Wenjing Zhang, Caijun Zha, Xiumin Lu, Ruichun Jia, Fei Gao, Qi Sun, Meili Jin, Yanhong Liu

Journal Article

Phase separation in cGAS-STING signaling

Journal Article

Inverse kinematics analysis and numerical control experiment for PRS-XY style hybrid machining tool

JIA Dongyong, ZHANG Jianmin, SUN Hongchang, NIU Zhigang

Journal Article

Integrated fuzzy lectotype optimization for pile－style foundations of offshore wind turbines

Zhai Gangjun,Li Yugang,Kang Haigui

Journal Article

Control of lupus activity during pregnancy via the engagement of IgG sialylation: novel crosstalk between IgG sialylation and pDC functions

Journal Article

Dynamic performance of submerged floating tunnel with different mooring styles subjected to anchor cable failure

Journal Article

Structure style selection and key structural design of herringbone steel middle pylon of three-pylon

Hua Xin,Han Dazhang,Zhou Yanfeng,Xu Ruifeng

Journal Article

Deep-seated Rupture Zone—a New Seismotectonic Style

Li Yuanjun

Journal Article

Qian Xuesen—An Example for Scientific and Technological Circles to Learn From

Tu Yuanji

Journal Article